SIGA requests priority FDA review of its oral smallpox drugSIGA Technologies of New York City announced yesterday that it has submitted its smallpox drug TPOXX (tecovirimat) for priority review by the US Food and Drug Administration (FDA).If approved, the oral drug would be the first FDA-approved treatment for smallpox, a disease that has been eradicated but could be used as a bioterror weapon. The news comes on the heels of media reports that North Korea could be building a bioweapons program that might include smallpox.TPOXX was developed to treat smallpox and other orthopoxvirus infections. SIGA has successfully delivered two million courses of TPOXX to the Strategic National Stockpile. No cure for smallpox currently exists, but lab personnel who work with smallpox or related viruses receive vaccination as a preventive measure.SIGA CEO Phil Gomez, PhD, said in a news release, “Based on extensive positive efficacy data in animal studies and human clinical safety data without any drug-related serious adverse events, we believe the NDA [new drug application] for oral TPOXX is well positioned for favorable, expedited review by the FDA.”SIGA expects to receive notification from the FDA in February 2018 that its filing was accepted for review, as well as confirmation of priority review status and notification of a final action date.Dec 11 SIGA news release Dec 11 CIDRAP News scan on North Korea bioweapons WHO: Flu on the rise in North America, parts of AsiaThe World Health Organization (WHO) released a new global influenza update yesterday, showing that influenza is on the rise in North America, Western and Central Asia, and Europe.In North America, the predominant strain has been influenza A, H3N2. Europe, however, has more influenza B circulating at this time. Both influenza A and B have been detected in Asia. In Western Africa, influenza A (H1N1) detections increased in Cote d’Ivoire and Ghana. Influenza B detections were reported in Central African Republic and Mozambique.The temperate zones of South America continue to report low influenza-like illness (ILI) activity. The Caribbean and Central America also report low ILI activity.Canada, the United States, and Mexico have all crossed the seasonal threshold for ILI. Adults over 65 have accounted for most influenza cases in the United States and just under half in Canada.Worldwide, laboratories reporting to the WHO have typed 62.5% of viruses as influenza A and 37.5% as influenza B.Dec 11 WHO update Cholera outbreaks reported in Kenya, ZambiaYesterday the WHO reported two outbreaks of cholera in Kenya and Zambia, with the Kenyan outbreak involving nearly 4,000 cases.Between Jan 1 and Nov 29, Kenyan officials have reported 3,967 probable and confirmed cases of cholera, including 76 deaths. Transmission has been linked to camps, institutions, and mass gatherings. Community transmission is still ongoing in 7 Kenyan counties as of Nov 29, but 20 of 47 counties (43%) in the country have documented cholera cases this year.The WHO said the risk of widespread transmission in Kenya is high. “Despite the decline in the number of cases reported, the outbreak appears to be clustered around two major types of settings. First, the refugee camps particularly Kakuma and Dadaab, and second in the populous Nairobi capital county,” the WHO explained.In Zambia, officials have reported 547 cases and 15 deaths since late September. Most cases are in the capital of Lusaka. The districts where cases have been documented have poor sanitation and water supply. A recent influx of refugees from the Democratic Republic of the Congo and the upcoming rainy season mean there’s a strong chance the outbreak will grow in the coming months, the WHO said.Dec 11 WHO Kenya reportDec 11 WHO Zambia report
USC’s Alan Knott named to the Rimington Award Spring Watch List.COLUMBIA – South Carolina sophomore center Alan Knott has been named to the Rimington Trophy Spring Watch List.The list includes 52 of the top centers in college football.The 6-4, 268-pound Tyrone, Georgia native made eight starts for the Gamecocks as a redshirt freshman and tool virtually all the snaps at center during spring practice.Following spring practice the USC coaching staff named him the most improved offensive lineman, in addition to being named the Joe Morrison Offensive Player of the spring, which was awarded at the spring game.The center with the most first-team votes will be determined the winner. If there is a tie with first team votes, then the center with the most second team votes will win. If there is still a tie, the winner will be determined by a majority vote from the Rimington Trophy committee. The winner will be recognized at the Rimington Trophy Presentation at the Rococo Theatre in Lincoln, Nebraska on Saturday, January 16, 2016.Dave Rimington, the award’s namesake, was a consensus first-team All-America center at the University of Nebraska in 1981 and 1982, during which time he became the John Outland Trophy’s only double winner as the nation’s finest college interior lineman.
George McEachran is the latest Chelsea youngster to move to the Netherlands on loan.The England Under-19 international has joined second-tier side SC Cambuur until the end of the season.Several Chelsea youngsters have spent time in Dutch football in recent years, largely because of the Blues’ partnership with Vitesse Arnhem.AdChoices广告[scriptless] See also:Brighton among clubs keen on Lamptey Embed from Getty Images Follow West London Sport on TwitterFind us on Facebook
Written By “In addition to building excitement across the country ahead of the Tokyo 2020 Games and promoting the Olympic values, the Olympic Torch Relay aims to demonstrate solidarity with the regions still recovering from the 2011 earthquake and tsunami,” the organisers said last month. Last Updated: 4th March, 2020 11:21 IST Japan Lifts Evacuation Order For Part Of Disaster-hit Fukushima Town Japan on Wednesday lifted an evacuation order for parts of Futaba, 1 of 2 towns where the crippled Fukushima nuclear plant is located, ahead of an Olympic relay SUBSCRIBE TO US COMMENT Press Trust Of India First Published: 4th March, 2020 11:21 IST The Japanese government is keen to use the Olympics to showcase Fukushima’s recovery from the disaster. It intends to use the J-Village — a sport complex located about 20 kilometres (12 miles) from the nuclear plant damaged in the 2011 tsunami — as the starting point for the Japan leg of the torch relay. The Fukushima crisis itself did not directly kill anyone, but some 470,000 people were estimated to have fled their home to seek shelter in the first days of the triple earthquake-tsunami-meltdown disaster. In all, 15,899 people died and 2,529 people remain missing after the quake and tsunami.Image credits: AP Japan on Wednesday lifted an evacuation order for parts of Futaba, one of two towns where the crippled Fukushima nuclear plant is located, ahead of an Olympic torch relay in the region. The whole of Futaba, formerly home to some 7,000 people, was designated a mandatory evacuation zone after a massive quake-triggered tsunami in 2011 hit the Fukushima Daiichi plant, damaging the power supply and cooling system and eventually causing a meltdown. With the lifting of the mandatory evacuation order in a northern part of the town, workers will be able to stay in the area near the main railway station.Japan lifts evacuation order But residents will not be able to return to the town immediately because of a shortage of running water and other infrastructure, a town official told AFP. “We are aiming to have the return of residents starting in the spring of 2022,” she said. The move comes after organisers of the Tokyo 2020 Olympics said Futaba has been added to the route for the Olympic torch relay, which begins on March 26. WATCH US LIVE LIVE TV FOLLOW US